Somatostatinoma

Somatostatinoma is a rare disease consisting in the malignant growth of delta cells located inside the endocrine pancreas. Due to the disorder, the latter produces too much of somatostatin. The increased levels of this hormone inhibit the production of pancreatic and gastrointestinal hormones. Therefore, somatostatinoma frequently results in diabetes mellitus, steatorrhoea, gallstones, or achlorhydria.

The endocrinologists of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine are always ready to help patients with these disorders. We have extensive experience in diagnosis and treatment of somatostatinoma and its consequences with people of all ages.

 

Causes of somatostatinoma

In most cases the causes of somatostatinoma remain unknown. As for the specific risk factors for such pathologies, they are as follows:

  • Type 1 multiple endocrine neoplasia;
  • Hereditary somatostatinoma or other pancreatic growths;
  • Neurofibromatosis or pheochromocytoma;
  • Molecular or genetic mutations resulting in tumor formations.

Specialists note that 95% of somatostatinomas occur sporadically, therefore it is very difficult to foresee and prevent the disease.

Symptoms of somatostatinoma

The signs of this disorder depend on the size and the place of the tumor. Generally, the symptoms of somatostatinoma are as follows:

  • Development of mild diabetes;
  • Fat indigestion;
  • Nausea or\and vomiting;
  • Stomach ache and back pain;
  • Bad appetite and loss of weight;
  • Diarrhea;
  • Skin yellowing;
  • Darkening of urine;
  • Fatigue;

Diagnosis of somatostatinoma

As a rule, it is very difficult to detect this disorder in its early stages. Nevertheless, the specialists of Tianjin hospital obtain perfect results in diagnostics of somatostatinoma with the use of the following methods:

  • Blood tests for serum amylase levels;
  • Blood tests for serum somatostatin levels;
  • Complete blood count with differential;

Blood tests for carcinoembryonic antigens, alpha fetoprotein, and so on.
Besides, our endocrinologists implement a number of clinical studies for diagnosis of somatostatinoma, among which:

  • Abdominal ultrasound;
  • Endoscopic ultrasound;
  • Abdomen CT scan;
  • MRI of abdomen;
  • MR cholangio-pancreatography and MR angiography;
  • Positron emission tomography scan;
  • Percutaneous transhepatic cholangiography;
  • Endoscopic retrograde cholangio-pancreatography;
  • Laparoscopy;
  • Laparotomy;
  • Tissue biopsy, etc.

We pay special attention to the thorough physical examination of the patient and the study of his medical history.

Treatment of somatostatinoma

In order to help the clients with somatostatinomas we apply to the newest achievements of medical science. The treatment of this disorder in Tianjin hospital is frequently conducted surgically. Our specialists remove the tumor from the endocrine pancreas. As a rule, the operation is followed by radiation therapy, as well as chemotherapy.

If the swelling has metastasized, we use the combination of chemotherapy, invasive procedures, and radiation therapy. The therapeutic regimen for every client is worked out in accordance with his physical data, general state of health, and the features of the pathology.

Here, at Tianjin hospital, we often apply to targeted therapy and biological therapy. The first includes the set of measures aimed at killing normal cancer cells and reducing the possibility of cancer spreading to other parts of the organism. Biological therapy or immunotherapy is connected with the use of certain bacteria, which can treat the tumor indirectly.

In order to cure somatostatinoma the specialists of our healthcare center use the ancient wisdom of Traditional Chinese Medicine. We treat people with this pathology by means of acupuncture, cauterization, massage, moxibustion, herbalism, and so on. Using such a many-sided therapeutic approach we achieve good and quick results in treatment of somatostatinoma irrespective of the severity of the disease.